Brevilin A
CAS No. 16503-32-5
Brevilin A ( —— )
Catalog No. M22858 CAS No. 16503-32-5
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 203 | In Stock |
|
10MG | 350 | In Stock |
|
25MG | 579 | In Stock |
|
50MG | 797 | In Stock |
|
100MG | 1071 | In Stock |
|
500MG | 2187 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameBrevilin A
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NoteResearch use only, not for human use.
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Brief DescriptionBrevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?
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DescriptionBrevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 =?10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumourIn vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima.?The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).?
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntifection
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RecptorAntifection;JAK;STAT
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Research Area——
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Indication——
Chemical Information
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CAS Number16503-32-5
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Formula Weight346.41
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Molecular FormulaC20H26O5
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (288.67 mM; Need ultrasonic)
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SMILESC/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Antiprotozoal activities of Centipeda minima. Phytother. Res., 1994, 8(8):436-8.
molnova catalog
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