Brevilin A ( —— )

Catalog No. M22858 CAS No. 16503-32-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Brevilin A
Note

Research use only, not for human use.
Brief Description

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?
Description

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 =?10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumourIn vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima.?The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).?
Synonyms

——
Pathway

Microbiology/Virology
Target

Antifection
Recptor

Antifection;JAK;STAT
Research Area

——
Indication

——

CAS Number

16503-32-5
Formula Weight

346.41
Molecular Formula

C20H26O5
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (288.67 mM; Need ultrasonic)
SMILES

C/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O
Chemical Name

——

1. Antiprotozoal activities of Centipeda minima. Phytother. Res., 1994, 8(8):436-8.

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