Brevilin A
CAS No. 16503-32-5
Brevilin A ( —— )
Catalog No. M22858 CAS No. 16503-32-5
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?
Purity : >98% (HPLC)
Size | Price / USD | Stock | Quantity |
5MG | 203 | In Stock |
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10MG | 350 | In Stock |
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25MG | 579 | In Stock |
|
50MG | 797 | In Stock |
|
100MG | 1071 | In Stock |
|
500MG | 2187 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameBrevilin A
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NoteResearch use only, not for human use.
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Brief DescriptionBrevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?
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DescriptionBrevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity.?Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 =?10.6 μM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumourIn vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima.?The sesquiterpene lactone, Brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).?
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntifection
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RecptorAntifection;JAK;STAT
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Research Area——
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Indication——
Chemical Information
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CAS Number16503-32-5
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Formula Weight346.41
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Molecular FormulaC20H26O5
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (288.67 mM; Need ultrasonic)
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SMILESC/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Myristicin
Myristicin is a natural product found in spices and umbelliferous plants.?Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway.?
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Viridicatol
Viridicatol, with potent antibacterial activity against Staphylococcus aureus(MIC: 15.6 μg/mL), is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum.
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Altenuene
Altenuene is a mycotoxin, it frequently occurs in food and feed items infested by fungi of the genus Alternaria. Altenuene demonstrates moderate activity against Staphylococcus aureus. Altenuene also exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1.